[RESUMEN] ABSTRACT

The faithful transfer of genome from parents to progeny is one of the most accurately controlled processes in cell division. DNA is the molecule bearing genetic information in all living organisms. DNA has to be duplicated to be transmitted from mother to daughter cells. In studying problems related to cell division and cancer, it is top priority to know the processes by which cells precisely regulate initiation of DNA replication. How do cells drive replication of their DNA?. Studies carried out during the last 5 years have pointed out that the same kinase activity which controls cell cycle progression, activates and inhibits the initiation of DNA replication. This apparent paradox ensures that genome replication precisely takes place only once each cell cycle. In studying problems related to cell division and cancer, it is crucial to understand how cells regulate initiation of DNA replication